Browsing by Author "Els, D."

Now showing 1 - 4 of 4
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    The effect of acute haemodilution during cardiopulmonary bypass on blood calcium, pH, phosphorus and protein values
    (Health & Medical Publishing Group, 1983) Coetzee, A. R.; Van der Merwe, W. L.; Taljaard, J. J. F.; Els, D.
    The changes in total serum calcium, ionized calcium, total serum proteins, albumin and phosphate levels during cardiopulmonary bypass were measured. The possible causes of the changes in these parameters are discussed. The effect of the presence of heparin on serum ionized calcium is evaluated. The metabolic and clinical significance of the changes in blood components measured are discussed, special attention being paid to the use of calcium as an inotropic agent at the termination of cardiopulmonary bypass.
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    The influence of contrast media on serum osmolality, haematocrit and cardiac output : a comparative study in dogs
    (Health & Medical Publishing Group, 1985) Van der Merwe, P. L.; Basset, A.; Els, D.
    Thirty-two mongrel dogs were used in a comparative study to assess the effect of normal saline solution, metrizamide and Cardioconray on serum osmolality, haematocrit and cardiac output. The study demonstrated that the higher the osmolality of the test substance, the greater the reduction in haematocrit and the higher the increase in cardiac output.
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    Primate endocrine function after pancreatico-duodenal-splenic allotransplantation
    (1987) Du Toit, D. F.; Heydenrych, J. J.; Smit, B.; Louw, G.; Zuurmond, T.; Els, D.; Weideman, A.; Wolfe-Coote, S.; Du Toit, L.; Gonin, R.; Davids, H.
    In this study the endocrine function following intraperitoneal hetero- and orthotopic pancreatico-duodenal-splenic allotransplantation (PDS) in hemipancreatectomized, non-immune-suppressed chacma baboons was assessed. Significantly reduced K-values and insulin release together with glucose intolerance during IVGTT were observed in hemipancreatectomized recipients (HPS) without grafts. Orthopic and heterotopic PDS transplantation improved the glucose intolerance of HPS recipients; orthotopically sited grafts rendering the best curves. Normal glucose tolerance was not achieved. Both orthotopic and heterotopic PDS transplantation rendered suboptimal insulin release during IVGTT; heterotopically draining grafts released signifcantly more insulin than orthotopic grafts. Hyperglucagonaemia during IVGTT was a constant feature in both groups, Heterotopic grafts releasing the most glucagon during stimulation. C-peptide release was significantly lower in orthotopic grafts compared to normal animals or heterotopically drained insulin. It is concluded that glucose tolerance was not directly related to insulin or glucagon release in this study as orthotopic grafts rendered near-normal IVGTT curves in the presence of hypoinsulinaemia, hyperglucagonaemia, and reduced C-peptide values. The hormonal response after PDS transplantation was variable and the advantages of portal vs systemic insulin drainage remain to be defined.
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    Die suurstofbalans in die normale hondmiokardium gedurende toenemende konsentrasies van inhalasienarkosemiddels
    (Health & Medical Publishing Group, 1988) Coetzee, A. R.; Fourie, P. R.; Badenhorst, E.; Els, D.
    Myocardial oxygen supply and demand in the normal dog were evaluated as the concentration of halothane, enflurane or isoflurane was increased. Although coronary blood flow decreased as the anaesthetic gas concentration increased, the O2 supply-to-demand ratio remained stable owing to a decrease in the myocardial O2 consumption.