Browsing by Author "De Klerk, A. J."

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    The effect of ventilatory patterns on prostacyclin (PGI2) synthesis in the lung
    (Health & Medical Publishing Group, 1984) Du Toit, H. J.; Erasmus, F. R.; Macfarlane, C. M.; Taljaard, J. F.; Shephard, E. G.; King, J. B.; De Klerk, A. J.
    Prostacyclin (PGI2) appears to be synthesized in the lungs of man and experimental animals. It has been stated that PGI2 must be regarded as a local hormone that inhibits platelet adhesion to vessel walls only very close to the site of synthesis. The wide range of normal values given for PGI2 may be related to the sensitivity and exclusiveness of the different assay techniques used. In animals, hyperventilation increases PGI2 synthesis by the lung, but in agreement with other authors we demonstrated that hyperventilation did not influence PGI2 synthesis in man. We used a radio-immunoassay technique to estimate PGI2 levels.
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    Methylprednisolone and the adult respiratory distress syndrome
    (Open access journal, 1984-06) Du Toit, H. J.; Erasmus, F. R.; MacFarlane, C. M.; Taljaard, J. J. F.; King, J. B.; De Klerk, A. J.; Elk, E.
    Total hip replacement was carried out on 22 patients under general anaesthesia. Of these, 10 were pretreated with methylprednisolone (30 mg/kg); 1 of these developed the adult respiratory distress syndrome (ARDS) and had high levels of thromboxane B2 (TXB2) 5 minutes after fixation of the femoral prosthesis and at the end of the operation. The other 12 patients served as controls; 5 of them developed ARDS and had statistically significant higher TXB2 levels than the other 7 control patients who remained well. All patients who did not develop ARDS had low TXB2 levels. TXB2 and β-thromboglobulin levels followed the same trend and there was good correlation (r = 0.6806; P < 0.01) at the end of the operation in the control group patients who developed ARDS. There was no statistical difference in 6-keto-PGF(1α) levels between the patients who developed ARDS and those in the control group who remained well. Steroids reduce arachidonic acid metabolism by inhibiting the release of substrate for cyclo-oxygenase and lipoxygenase activity. Patients prone to ARDS thus benefit from methylprednisolone administration.
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    Resultate van die Austin Moore-prostese in intrakapsulere femurnekfrakture in Tygerberg-Hospitaal : 'n retrospektiese ondersoek
    (Health & Medical Publishing Group, 1990) Van der Merwe, D. F.; De Klerk, A. J.; Vlok, G. J.
    A retrospective study was done on 116 patients who received an Austin Moore prosthesis at Tygerberg Hospital between 1982 and 1983. The patients all had displaced intracapsular femoral neck fractures (Garden type III or IV). Although the Moore prosthesis must be fitted meticulously for good results, the operation can be performed effectively by the less experienced surgeon. This cementless monoprosthesis is a good option for the elderly and/or poor-risk patient with a limited life expectancy. It has a low intraoperative mortality, a low percentage of re-operation and results in early and good mobilisation. In contrast to series on cemented prosthesis, we had a very low sepsis rate. In comparison to a total hip replacement, this is much cheaper prosthesis and operation.