Browsing by Author "Burger, Robert William"

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    Flux balance analysis of Plasmodium falciparum growth and energy metabolism
    (Stellenbosch : Stellenbosch University, 2017-12) Burger, Robert William; Snoep, Jacky L.; Eicher, J.; Stellenbosch University. Faculty of Science. Dept. of Biochemistry.
    ENGLISH ABSTRACT: Genome-scale network reconstructions serve as an ideal tool for the modeling of large, complex metabolic networks. In this study we use ux-balance analysis to investigate key amino acid dependencies of Plasmodium falciparum growth. Our model was able to produce a realistic ux distribution geared for the optimal production of biomass. We were able to simulate parasite growth in a variety of conditions and assess the favourability of these conditions for optimal growth. To demonstrate the applicability of the model we additionally simulate the response of the model to the introduction of an antimalarial agent, atovaquone.