Cardiothoracic Surgery

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Browsing Cardiothoracic Surgery by Author "Janson, P. M. C."

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    Aneurysm of a peripheral pulmonary artery : case report and brief review of the literature
    (Health and Medical Publishing Group (HMPG), 1975-08) Janson, P. M. C.; Barnard, P. M.; Weich, H. F. H.; MacMahon, A. G.
    A patient is presented in whom a solitary aneurysm of a peripheral pulmonary artery was treated by left lower lobectomy. This is the eighth reported successful resection of such an aneurysm. A brief review of the literature is also presented and the importance of pulmonary arteriography in the diagnosis of this condition is mentioned.
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    Lysosomal disruption during the development of endotoxic shock in the baboon
    (Health and Medical Publishing Group (HMPG), 1975-06) Janson, P. M. C.; Kuhn, S. H.; Geldenhuys, J. J.
    Lysosomal disruption with release of lysosomal enzymes has been described in shock. This study was designed to demonstrate the release of lysosomal enzymes in the liver and lung in addition to determining circulating serum lysosomal enzyme values. Therapeutic means of reducing or inhibiting lysosomal disruption were also investigated. Five groups of baboons were investigated: Group A: (control group) - no endotoxin or treatment administered. Group B: (endotoxin only) - liver and lung tissues showed an increase in free lysosomal enzymes, and a similar increase in circulating serum lysosomal enzymes was demonstrated. Group C: (chloroquine treatment (lysosomal stabiliser) following endotoxin administration) - the liver and lung tissues showed a smaller increase in free lysosomal enzymes and a corresponding lesser increase in circulating serum lysosomal enzymes was demonstrated. Group D: (dexamethasone treatment (lysosomal membrane stabiliser) following endotoxin administration) - the rise in lysosomal tissue and serum enzyme values was less than that in group B. Group E: (combination of chloroquine and dexamethasone treatment following endotoxin administration) - the rise in lysosomal tissue and serum values was less than that demonstrated in group B. The survival of the animals in the various groups correlated well with the lysosomal enzyme tissue and serum values, as did the monitored haemodynamic, haematological and other parameters.
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    Penetrating wounds of the heart and great vessels : experience with 24 cases including 3 with intracardiac defects
    (Health and Medical Publishing Group (HMPG), 1975-03) De Wet Lubbe, J. J.; Janson, P. M. C.; Barnard, P. M.
    Twenty four cases of penetrating cardiac injuries due to stab wounds, which were seen over a 3 yr period, are reviewed. Ten patients were treated by aspiration alone because tamponade was mild, or because they were seen more than 12 hr after injury. One patient with multiple stab wounds in the ventricles and left atrium died during emergency thoracotomy in the admission room. The mortality rate of 4.2% is considerably lower than rates reported in other series. Two cases of traumatic ventricular septal defects, one case of traumatic aortic incompetence and sinus of Valsalva fistulae with rupture into the right ventricle and right atrium, and one case of ascending aorta innominate vein fistula are discussed. A plan of management is outlined.
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    Ventrikulere aneurismektomie en infarktektomie
    (Health and Medical Publishing Group (HMPG), 1975-03) Barnard, P. M.; De Wet Lubbe, J. J.; Janson, P. M. C.
    Four patients underwent ventricular aneurysmectomy for congestive cardiac failure. In addition, 1 patient with an aneurysm and 3 patients with acute myocardial infarcts, ranging from 16 to 28 days postinfarction, underwent emergency surgery for recurrent malignant arrhythmias. The preoperative treatment, cardiac catheterization data and surgical findings are outlined. The overall survival rate is 75% for a mean followup period of 12.5 mth (range 8-22 mth). It is concluded that aneurysmectomy, for congestive cardiac failure, and infarctectomy, for life threatening ventricular arrhythmias, are gratifying and worthwhile procedures.