Research Articles (Radiation Oncology)

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Browsing Research Articles (Radiation Oncology) by Author "Barnardt, Pieter"

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    Gestational trophoblastic neoplasm and women living with HIV and/or AIDS
    (AOSIS Publishing, 2015-07-03) Barnardt, Pieter; Relling, Martha
    The 2011 World Health Organization global report on HIV and/or AIDS estimated that sub-Saharan Africa comprised 67% of the global HIV burden, with a current estimate of 5.9 million cases in South Africa. Since the introduction of antiretroviral therapy, there has been an increase in the incidence of non-AIDS-defining cancers. Gestational trophoblastic neoplasm (GTN) is a rare pregnancy-related disorder with an incidence ranging from 0.12–0.7/1000 pregnancies in Western nations. The overall cure rate is about 90%. Response to treatment for GTN is generally favourable; but the sequelae of HIV and/or AIDS, the resultant low CD4 counts, comorbidities, poor performance status and the extent of metastatic disease in patients receiving chemotherapy, compromise the prognosis and survival.
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    Managing AIDS-related Kaposi’s sarcoma and pregnancy
    (AOSIS Publishing, 2013-05) Barnardt, Pieter
    An estimated 30 - 40% of HIV-infected patients are likely to develop cancer during the progression of their disease. The occurrence of malignancy among these patients represents a difficult challenge in their care. Kaposi’s sarcoma (KS) – currently the most common tumour observed with an estimated incidence of 15 - 20% – represents the first manifestation of AIDS in 30 - 40% of patients. Any organ may be involved, but the gastrointestinal tract and lung remain the most frequently involved locations. The case described here presented a clinical and ethical dilemma where visceral KS, pregnancy and medical complications required multi-disciplinary management.
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    Managing gestational trophoblastic neoplasm (GTN) and people living with HIV (PLWH)
    (MedPharm Publications, 2019) Barnardt, Pieter
    The 2017 World Health Organization (WHO) global report on HIV/AIDS estimated that sub-Saharan Africa comprised 64% of the global HIV burden, with a current estimate of 19.4 million cases in Eastern and Southern Africa. Since the introduction of antiretroviral therapy (ART) there has been a 30–40% increase in the incidence of non-AIDS malignancies. Gestational trophoblastic disease comprises of a spectrum of pregnancy-related disorders with an overall cure rate of 90%. The response to treatment is generally favourable but the associated complications of HIV, comorbidities, poor performance status and extent of metastatic disease in gestational trophoblastic neoplasm patients receiving chemotherapy, compromises the outcome and survival.
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    Ovarian germ cell tumour and bleomycin-induced lung injury
    (Medpharm Publications, 2018) Barnardt, Pieter; Griffith-Richards, Stephanie
    Bleomycin, an antibiotic agent with antitumour activity, is an important drug in the management of many oncological malignancies such as lymphoma and germ cell tumours. These tumours are potentially curable and mostly affect young people. The potential side effects and long-term toxicities should be considered. The major limitation of bleomycin therapy is pulmonary toxicity and may be life threatening in about 10% of cases. This article reports a case of an ovarian mixed germ cell tumour, which presented with bleomycin-associated pulmonary toxicity.
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    Primary breast lymphoma and HIV/AIDS
    (AOSIS OpenJournals, 2011-09) Barnardt, Pieter; Narinesingh, Dylan
    Primary extranodal lymphoma of the breast is rare and accounts for 0.04 - 0.53% of all malignant tumours, less than 1% of non-Hodgkin’s lymphomas (NHLs) and 1.7% of extranodal NHLs.1 Extranodal lymphoma arises from tissue other than lymph nodes and sites that normally contain no lymphoid tissue. This case describes the clinical and treatment dilemma posed by extranodal presentation in an AIDS-NHL patient.