Department of Paediatrics and Child Health

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Browsing Department of Paediatrics and Child Health by browse.metadata.advisor "Bezuidenhout, Heidre"

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    The Outcomes of infants with Edward Syndrome and Patau Syndrome in a resource restricted environment
    (Stellenbosch : Stellenbosch University, 2021-12) Da Costa, A'ishah; Van Wyk, Lizelle; Bezuidenhout, Heidre; Stellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Paediatrics and Child Health.
    ENGLISH ABSTRACT: Introduction: Edward and Patau syndrome are two of the more common neonatal aneuploidies. Few infants are documented as surviving past 18-months of age. We aim to describe the outcome and palliative care plans of infants with Edward and Patau syndrome admitted to a resource restricted hospital in Cape Town, South Africa. Methods: A retrospective descriptive review of neonates admitted to Tygerberg Hospital over a 5-year period (2013- 2018) was performed. Neonates with a presumptive diagnosis of Edward and Patau syndrome were included. Other trisomy and congenital disorders were excluded, as well as neonates with missing files. Results: Thirty-five neonates (Edward syndrome (n=22), Patau syndrome (n=13)) were included. The most common congenital abnormalities in Edward syndrome were limb (91%), ear (86%) and cardiac (73%) anomalies, and in Patau syndrome were limb (100%), head (92%) and ear (85%) anomalies. In-hospital mortality for Patau syndrome neonates was 61% with an overall-mortality of 84%. In-hospital mortality for Edward syndrome neonates was 45% with an overall-mortality of 77%. In-hospital palliation-only management was documented for 85% and 95% of neonates with Patau and Edward syndrome, respectively. However, post discharge/ transfer palliative care plans were only documented for 38% and 63% of neonates with Patau and Edward syndrome, respectively. Conclusion: This is the first study at Tygerberg Hospital, a resource restricted hospital, to describe the outcomes of neonates with Edward syndrome and Patau syndrome. The majority of neonates demised within the immediate neonatal period. Although in-hospital palliative care plans were well documented, post-discharge/ transfer palliative care plans were poorly documented.