(Stellenbosch : University of Stellenbosch, 1996-12) Parkin, Donald Pysden; Donald, P. R.; Van Jaarsveld, P. P.; University of Stellenbosch. Faculty of Health Sciences. Dept. of Medicine. Pharmacology.
The work presented in this thesis has contributed to the clarification of a number of issues related to the clinical pharmacokinetics of isoniazid and hydrozine in juvenile and adult patients of both sexes subject to potentially deleterious environmental factors: acute tuberculous disease; nutritional deprivation; simultaneous ingestion of rifampicin, pyrazinamide and ethionamide, each of which is potentially toxic in its own right. The advances are embodied in the developments listed here below. ...