(Stellenbosch : Stellenbosch University, 2017-12) Burger, Robert William; Snoep, Jacky L.; Eicher, J.; Stellenbosch University. Faculty of Science. Dept. of Biochemistry.
ENGLISH ABSTRACT: Genome-scale network reconstructions serve as an ideal tool for the modeling of
large, complex metabolic networks. In this study we use
ux-balance analysis to
investigate key amino acid dependencies of Plasmodium falciparum growth. Our
model was able to produce a realistic
ux distribution geared for the optimal
production of biomass. We were able to simulate parasite growth in a variety of
conditions and assess the favourability of these conditions for optimal growth.
To demonstrate the applicability of the model we additionally simulate the response
of the model to the introduction of an antimalarial agent, atovaquone.