Epidemiology, health systems and stakeholders in rheumatic heart disease in Africa : a systematic review protocol

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dc.contributor.authorMoloi, Annesinah Hlengiween_ZA
dc.contributor.authorWatkins, Daviden_ZA
dc.contributor.authorEngel, Mark E.en_ZA
dc.contributor.authorMall, Sumayaen_ZA
dc.contributor.authorZuhlke, Lieslen_ZA
dc.date.accessioned2017-08-03T13:40:07Z
dc.date.available2017-08-03T13:40:07Z
dc.date.issued2016
dc.descriptionCITATION: Moloi, A. H., et al. 2016. Epidemiology, health systems and stakeholders in rheumatic heart disease in Africa : a systematic review protocol. BMJ Open, 6:e011266, doi:10.1136/ bmjopen-2016-011266en_ZA
dc.descriptionThe original publication is available at http://bmjopen.bmj.comen_ZA
dc.description.abstractntroduction: Rheumatic heart disease (RHD) is a chronic disease affecting the heart valves, secondary to group A streptococcal infection (GAS) and subsequent acute rheumatic fever (ARF). However, RHD cure and preventative measures are inextricably linked with socioeconomic development, as the disease mainly affects children and young adults living in poverty. In order to address RHD, public health officials and health policymakers require up-to-date knowledge on the epidemiology of GAS, ARF and RHD, as well as the existing enablers and gaps in delivery of evidence- based care for these conditions. We propose to conduct a systematic review to assess the literature comprehensively, synthesising all existing quantitative and qualitative data relating to RHD in Africa. Methods and analysis: We plan to conduct a comprehensiveliteraturesearchusinganumberof databases and reference lists of relevant articles published from January 1995 to December 2015. Two evaluators will independently review and extract data from each article. Additionally, we will assess overall study quality and risk of bias, using the Newcastle-Ottawa Scale and the Critical Appraisal Skills Programme criteria for quantitative and qualitative studies, respectively. We will meta-analyse estimates of prevalence, incidence, case fatality and mortality for each of the conditions separately for each country. Qualitative meta-analysis will be conducted for facilitators and barriers in RHD health access. Lastly, we will create a list of key stakeholders. This protocol is registered in the PROSPERO International Prospective Register of systematic reviews, registration number CRD42016032852en_ZA
dc.description.urihttp://bmjopen.bmj.com/content/6/5/e011266
dc.description.versionPublisher's versionen_ZA
dc.format.extent9 pagesen_ZA
dc.identifier.citationMoloi, A. H., et al. 2016. Epidemiology, health systems and stakeholders in rheumatic heart disease in Africa : a systematic review protocol. BMJ Open, 6:e011266, doi:10.1136/ bmjopen-2016-011266en_ZA
dc.identifier.issn2044-6055 (online)
dc.identifier.otherdoi:10.1136/bmjopen-2016-011266
dc.identifier.urihttp://hdl.handle.net/10019.1/102046
dc.language.isoen_ZAen_ZA
dc.publisherBMJ Publishing Groupen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectRheumatic heart disease -- Africaen_ZA
dc.subjectMedical protocols -- Africaen_ZA
dc.subjectRheumatic fever -- Africaen_ZA
dc.subjectStreptococcal infectionsen_ZA
dc.titleEpidemiology, health systems and stakeholders in rheumatic heart disease in Africa : a systematic review protocolen_ZA
dc.typeArticleen_ZA
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