Antiviral efficacy and safety of abacavir-containing combination antiretroviral therapy as first-line treatment of HIV-infected children and adolescents : a systematic review protocol

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dc.contributor.authorAdetokunboh, Olatunji O.en_ZA
dc.contributor.authorSchoonees, Anelen_ZA
dc.contributor.authorWiysonge, Charles S.en_ZA
dc.date.accessioned2014-09-04T12:20:36Z
dc.date.available2014-09-04T12:20:36Z
dc.date.issued2014-08
dc.descriptionPublication of this article was funded by the Stellenbosch University Open Access Fund.en_ZA
dc.descriptionThe original publication is available at http://www.systematicreviewsjournal.com/content/3/1/87en_ZA
dc.descriptionAdetokunboh, O.O., Schoonees, A. & Wiysonge, C.S. 2014. Antiviral efficacy and safety of abacavir-containing combination antiretroviral therapy as first-line treatment of HIV-infected children and adolescents: a systematic review protocol. Systematic Reviews, 3(87), doi:10.1186/2046-4053-3-87.en_ZA
dc.description.abstractAbstract Background: Abacavir is one of the recommended nucleoside reverse transcriptase inhibitors (NRTIs) for the treatment of HIV infections among children and adolescents. However, there are concerns that the antiviral efficacy of abacavir might be low when compared to other NRTIs especially among children. There are also concerns that abacavir use may lead to serious adverse events such as hypersensitivity reactions and has potential predisposition to developing cardiovascular diseases. Methods: We plan to do a systematic review to evaluate the antiviral efficacy and safety of abacavir-containing combination antiretroviral therapy as first-line treatment of HIV-infected children aged between 3 months and 18 years, compared with other NRTIs. We will search Scopus, Cochrane Central Register of Controlled Trials, MEDLINE, and Web of Science databases for eligible studies regardless of language or publication status. We will check the reference lists of included studies, search relevant conference proceedings, email the authors of included studies and also look for unpublished and ongoing trials in prospective clinical trial registries. Two authors will independently screen search outputs, select studies, extract data and assess the risk of bias in included studies. All disagreements will be resolved by discussion and consensus. Where data allow, we will conduct meta-analysis for similar types of participants, study designs, interventions, and outcome measures. If the results are statistically homogeneous, we will use the fixed-effect model; otherwise, we will use the random-effects model and explore the reasons for heterogeneity using subgroup analyses. Heterogeneity will be assessed with the Chi-squared test and quantified with the I-squared statistic. Discussion: The findings will be useful to policy makers and programme managers to inform treatment and management of HIV in children and adolescents and to point out research gaps for future research. Trial registration: This review is registered with PROSPERO, registration number CRD42014009157.en_ZA
dc.description.sponsorshipStellenbosch Universityen_ZA
dc.description.versionPublishers' Versionen_ZA
dc.format.extent6 pages
dc.identifier.citationAdetokunboh, O.O., Schoonees, A. & Wiysonge, C.S. 2014. Antiviral efficacy and safety of abacavir-containing combination antiretroviral therapy as first-line treatment of HIV-infected children and adolescents: a systematic review protocol. Systematic Reviews, 3(87), doi:10.1186/2046-4053-3-87.en_ZA
dc.identifier.issn2046-4053 (Online)
dc.identifier.otherdoi:10.1186/2046-4053-3-87
dc.identifier.urihttp://hdl.handle.net/10019.1/95549
dc.language.isoen_ZAen_ZA
dc.publisherBioMed Centralen_ZA
dc.rights.holderAuthors retain copyright.en_ZA
dc.subjectAntiretroviral therapyen_ZA
dc.subjectAbacaviren_ZA
dc.subjectHIV infections -- Treatmenten_ZA
dc.subjectAntiretroviral agentsen_ZA
dc.subjectHIV-positive childrenen_ZA
dc.subjectAIDS (Disease) in adolescentsen_ZA
dc.titleAntiviral efficacy and safety of abacavir-containing combination antiretroviral therapy as first-line treatment of HIV-infected children and adolescents : a systematic review protocolen_ZA
dc.typeArticleen_ZA
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