(Official Organ of Wroclaw University of Medicine, 2011) Tchokonte-Nana, Venant; Longo-Mbenza, Benjamin; Page, Benedict J.; Du Toit, Donald F.
This review focuses on recent progress in understanding morphogenetic findings on the neogenesis of islet beta
cells following Pancreatic Duct Ligation (PDL) in animal models. These results may give hope for modifications
in the treatment of diabetes in general and transplantation in particular. On the basis of this review, translational
studies should be developed to allow information on beta-cell neogenesis to be integrated into a potential therapy
for Diabetes Mellitus (DM) in humans. Further studies on the development of animal models that will produce
PDL islets for transplantation are urgently needed.